Psilocybin Microdosing Protocols: Fadiman vs Stamets vs Every Day

## The Short Answer The three most common microdosing protocols are: **Fadiman** (1 day on, 2 days off — the most studied), **Stamets** (4 days on, 3 days off — includes lion's mane and niacin), and **Every Day** (daily — not recommended due to rapid tolerance development). The Fadiman protocol is the most commonly recommended starting point because it allows clear comparison between microdosing and non-microdosing days, prevents tolerance, and has the most observational data. ## Protocol Comparison | Protocol | Schedule | Dose | Best For | |---|---|---|---| | Fadiman | Day 1 on, Day 2-3 off | 0.1–0.3g | General use, beginners | | Stamets | 4 days on, 3 days off | 0.1–0.2g + lion's mane + niacin | Neuroplasticity, cognitive enhancement | | Every Day | Daily | 0.05–0.1g | Not recommended (tolerance) | | Intuitive | As needed | Variable | Experienced users only | ## The Fadiman Protocol Developed by James Fadiman based on observational data from hundreds of self-reporters. The 1-on, 2-off schedule prevents tolerance (psilocybin tolerance develops within 24–48 hours) and allows clear comparison between microdosing and non-microdosing days for tracking effects. ## The Stamets Protocol Developed by mycologist Paul Stamets. Adds lion's mane mushroom (for NGF stimulation) and niacin (as a "flush" to drive the compounds into the nervous system) to psilocybin. The 4-on, 3-off schedule is more aggressive. Stamets claims synergistic neuroplasticity effects from the combination. ## Which Protocol to Start With For most people, the Fadiman protocol is the best starting point. It is the most studied, the most forgiving, and provides the clearest feedback on effects. Start at 0.1g and adjust based on response. [See the full protocol →](/research-checkout) *This article is for informational purposes only and does not constitute medical advice.*